Fibroblast Growth Factor-1 Stimulates Branching and Survival of Myocardial Arteries
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor-1 stimulates branching and survival of myocardial arteries: a goal for therapeutic angiogenesis?
Fibroblast growth factors (FGFs) were among the first molecules discovered to stimulate the growth of endothelial cells. Now, more than 15 years after their initial discovery,1 we still do not understand what endogenous role they play in embryonic and pathological angiogenesis. Both acidic FGF (FGF-1) and basic FGF (FGF-2) lack a typical secretion signal, their spatiotemporal expressions do not...
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Fibroblast growth factors (FGFs) were among the first molecules discovered to stimulate the growth of endothelial cells. Now, more than 15 years after their initial discovery,1 we still do not understand what endogenous role they play in embryonic and pathological angiogenesis. Both acidic FGF (FGF-1) and basic FGF (FGF-2) lack a typical secretion signal, their spatiotemporal expressions do not...
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BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
متن کاملTransgenic myocardial overexpression of fibroblast growth factor-1 increases coronary artery density and branching.
Fibroblast growth factor (FGF)-1 plays important roles during myocardial and coronary morphogenesis. FGF-1 is also involved in the physiological response of the adult heart against ischemia, which includes cardiomyocyte protection and vascular growth. In the present study, we have generated transgenic mice with specific myocardial overexpression of the gene. Transgene expression was verified by...
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Introduction Angiotensin converting enzyme (ACE) activity contributes to the vascular response to injury because ACE inhibition limits neointima formation in rat carotid arteries after balloon injury. To investigate the mechanisms by which ACE may contribute to vascular smooth muscle cell (VSMC) proliferation, we studied expression ofACE in vivo after injury and in vitro after growth factor sti...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.87.3.176